Product Code Database
The aortic sac or aortic bulbAnnalisa Berta, James L. Sumich, Kit Kovacs. Marine Mammals: Evolutionary Biology. Academic Press, 2006; page 240. is a dilated structure in , lined by endothelium cells and is the most distal part of the truncus arteriosus. It is the primordial vascular channel from which the aortic arches arise (and eventually the ) and is homologous to the ventral aorta of gill-bearing vertebrates. The aortic sac eventually forms right and left horns, which subsequently give rise to the brachiocephalic trunk and the proximal segment of the Aortic arch, respectively.
HAND2 ( dHAND) and HAND1 ( eHAND) are expressed during the development of the aortic bulb and the arteries which arise from it.Richard P. Harvey, Nadia Rosenthal (ed). Heart Development. Gulf Professional Publishing, 1999; page 150-151. The protein encoded by these genes belong to the basic helix-loop-helix family of transcription factors.
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